Recurrent Pregnancy Loss

Recurrent pregnancy loss (RPL) is defined as 3 consecutive miscarriages occurring at less than 20 weeks of Gestation. Based on this definition, RPL affects 1-2% of all fertile couples.

For a definitive evaluation for the possible causes below, please make an appointment with an FCI physician by calling 1-877-324-4483 or Request Appointment Online.

Possible Causes of Recurrent Pregnancy Loss

Chromosomal abnormalities – This is an abnormality with the genetic material of a Embryo and usually occurs when the chromosomes from the egg and the sperm fail to line up correctly. This can result from flawed genetic material (a translocation) from the mother or father that does not affect the mother or father’s health but can prevent an embryo from developing correctly. Because the baby only inherits half of each parent’s genes, there is still chance of creating a healthy baby if the defect is not transmitted or spontaneously corrects itself when the embryo is created.

Uterine abnormalities – If your Uterus is anatomically “abnormal” or divided, such as a uterine septum (the most common uterine abnormality), the embryo either can’t implant or gets undernourished early in the pregnancy.

Hypo or Hyperthyroidism – A very common hormonal issue affecting many women. Symptoms can be very subtle and can present with recurrent miscarriages only.

Hyperprolactinemia – An important Hormone produced by your brain that has multiple effects but has significant reproductive impact on the uterus if elevated.

Advanced maternal age - >35 and egg quality - As all women realize, their fertility decreases as they age. This can affect their ability to get pregnant but also affect their ability to keep a pregnancy.

Uncontrolled diabetes – elevated insulin levels and glucose levels can result in increased risk of miscarriage.

Polycystic Ovarian Syndrome (PCOS) - Click for details.

Immunologic disorders – A very controversial field. Many treatments are considered experimental but heparin and baby aspirin in certain medical situations may be indicated and proven beneficial. An evaluation to determine whether patients with RPL have antiphospholipid antibody syndrome or anticardiolipin antibodies are the only immune antibodies that have been clearly associated with RPL. Therapy has shown to improve retention rates for ongoing pregnancy.

Environmental – Smoking, alcohol and recreational drugs have all been associated with increased miscarriage rates. Cessation of such therapy is recommended.

Bacterial infection – controversial area in which two bacteria, in particular – mycoplasma hominis and ureaplasma urealyticum – can raise the risk of miscarriage. However, there are no definitive studies that show that these bacteria in the vaginal/cervical flora cause miscarriages or that treatment improves pregnancy outcome.

Thrombophilia – Miscarriages have been associated with a hypercoagulable state or an ability to clot blood more than normal. Such clotting is important is preventing bleeding but clots can also block valuable blood supply to a pregnancy. Various tests have been developed to check for a propensity to clot. It is controversial whether or not to check for such abnormalities in the general recurrent miscarriage population. Patients with a history of 2nd or 3rd trimester loss, leg thrombosis in their personal history or unexplained high order (>3) recurrent miscarriage should have a thrombophilia workup.

Potential Therapies

Regarding the necessity of any of these therapies below, please consult an FCI physician by calling 1-877-324-4483 or Request Appointment Online.

As we learn more about genetics, embryology, immunology and blood clotting, we have developed better diagnostic tests into causes of miscarriage. While treatment of anatomic and hormonal abnormalities will clearly improve pregnancy outcomes. there are few definitive therapies that have been clearly shown to decrease miscarriage rates due to other factors.

Preimplantation genetic diagnosis (PGD)

Click for details.

Surgery

Depending on the type, uterine abnormalities can be corrected surgically. Surgical Correction of a uterine septum (where the uterine cavity is divided in half) has been shown to be extremely beneficial for RPL. Although overall rare in the general population, uterine septi can affect 10-15% of those who suffer from repeated pregnancy losses.

Thyroid and Prolactin medical therapies

Abnormalities with the thyroid and prolactin can be easily treated with simple medical therapy.

Immunotherapy

Immunology is the most hotly contested field of research for miscarriages. The basic theory is that an embryo consists of material from the mother and “foreign” material from the father. This foreign material is recognized by the mother’s hyper-immune system and is attacked. Research surrounds therapy to reduce the recognition of “foreign” material or inhibit the destruction of foreign material, in this case, the pregnancy.

Current immunotherapy, i.e. IV IgG, is considered experimental and there are no randomized studies that validate its usage outside of research protocols. Any immunotherapy available is considered “off-label” (FDA approved drug that is being used in an unapproved manner). FCI follows the American Society of Reproductive Medicine guidelines that warns that such therapy has no long-term data yet proving that it has any beneficial effect. Other “promising” therapies are often proven to be ineffective and therefore a conservative approach is warranted until more definitive data and research is complete.

Anticoagulant therapy

Those patient diagnosed with Antiphospholipid Syndrome (APL) may benefit from therapy. Antiphospholipid antibodies and anticardiolipin antibodies are auto antibodies that may lead to reduced blood flow to a pregnancy and cause an increase the tendency of the blood to clot.

Women with RPL have an increased risk of having APL and treatment with heparin and baby aspirin during early pregnancy can reduce a pregnancy loss by 50%.

Such therapy, although promising, on occasion has been applied to other medical situations such as unexplained Infertility without any definitive data regarding its benefit. Because heparin and aspirin are not completely risk-free and can have significant side effects, FCI believes that such therapy should be reserved for those with a definitive diagnosis of APL.

Anti-insulin therapy

Women with PCOS, a specific reproductive disorder that can result in irregular cycles and elevated male hormone levels, may benefit from a diabetic drug called metformin during early pregnancy.